Officers stopped and searched 38 buses, checked other vehicles for compliance with the new traffic law and visited night clubs.
Officers were accompanied by immigration agents and agents from the Patronato Nacional de la Infancia, the child welfare agency.
For all their work, police detained just one man who was the subject of an arrest warrant. However, marijuana, crack cocaine and drug paraphernalia were confiscated, officers said.
The sweep was Friday and all day Saturday. Police also set up checkpoints on the highway. Involved were the dogs of the Unidad Canina, officers said. They are skilled at sniffing out drugs.
Some 62 motorists got tickets. A motorcycle that has been reported stolen turned up, officers said.