Gunmen cut down a man on the public right-of-way in Dos Cercas de Desamparados, and Fuerza Pública officers were able to detain two suspects a short time later.
Desamparados has been plagued for months by shootings and murders that have been attributed to rival drug gangs.
The man who died has the last name of Zamora, said the Judicial Investigating Organization. He was known to police because family members have been well-known criminals.
Fuerza Pública officers on patrol said they spotted two men acting suspiciously when they entered a white vehicle.
Seconds later they heard about the shooting and followed the men who tried to elude police by pulling the car into a garage.
They were identified as a 19 year old and a 24 year old who have police records. Officers said that they saw a weapon being thrown from the car during a brief chase. A 9-mm pistol was recovered by judicial agents. The victim died from bullets fired by a 9-mm. weapon.
The shooting took place around 11 a.m. Zamora, 44, was dead at the scene.
Police said there may have been a third individual involved in the shooting, but just two were detained after brief foot chases.
Judicial agents said the firearm would be checked for possible use in other murder cases.